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The path to Self Employment

I have often told people how I started Quickscrews over 25 years ago. Rarely do I ever explain why I did it. As a young man coming out of college at age 24 with a degree in business I started out working in a construction company as a cost analyst. I worked for a small privately held company where the owner and his partner were very active in running the company. I worked in the operations department which was responsible for running the crews that were doing the building.

Time to Reflect

At this time of year it is nice to take a few moments to reflect on how we are doing. I have been working hard this year on improving both my professional and personal life. In business I often take a good deal of time to analyze what we have done; then evaluate our options and lastly design a course of action consistent with the results of those processes. I find I rarely do that in my personal life. I will try harder. As my wife, Deb and I were raising 3 boys who were two years apart there wasn't a whole lot of time for analysis, just a whole lot of doing.

Fiscal Unreality

In the Beginning

It was over 25 years ago that I started Quickscrews in my garage in San Mateo, California. I was a nail and staple salesman at 29 years old and decided I wasn't cutout to work for others. I was stubborn and strong headed to say the least. I had the gift of gab and could have been a salesmen anywhere. My flaw was I always wanted things to be perfect. I would point out to any supervisor I had exactly what they were doing wrong and why. That often did not sit well with the owners of those companies I worked for.

This Weeks News

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nanosponge

Nanoengineers at the University of California, San Diego say they have created a "nanosponge" that is capable of safely removing a broad class of dangerous substances from the bloodstream - including toxins produced by MRSA, E. coli, venomous snakes, and bees.

In a study using the toxin from MRSA, inoculation with nanosponges enabled 89 percent of mice to survive lethal doses. The team has published details of their work in Nature Nanotechnology.

Researcher Liangfang Zhang said nanosponges can neutralize a range of pore-forming toxins, which destroy cells by poking holes in the cell membrane. Unlike other anti-toxin treatments that need to be custom synthesized for individual toxin type, the nanosponges can absorb different pore-forming toxins regardless of their molecular structures.

The nanosponge is made of a biocompatible polymer core wrapped in segments of red blood cell membrane, allowing it to evade the immune system and remain in circulation in the bloodstream while it collects the toxins.

The researchers are aiming to translate this work into approved therapies as quickly as possible. "One of the first applications we are aiming for would be an anti-virulence treatment for MRSA. That's why we studied one of the most virulent toxins from MRSA in our experiments," said co-researcher "Jack" Che-Ming Hu. The next step, he added, is to pursue clinical trials.

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